Acute Tubulointerstitial Nephritis | SpringerLink


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Acute Tubulointerstitial Nephritis (AIN) Research Summary

This resource compiles a collection of research articles focusing on acute tubulointerstitial nephritis (AIN), a kidney inflammation. The articles cover various aspects of the disease, including its prevalence, clinical features, diagnosis, treatment, and long-term outcomes.

Key Research Areas Covered:

  • Prevalence and Etiology: Studies explore the increased prevalence of AIN and investigate its diverse causes, such as drug-induced reactions (NSAIDs, proton pump inhibitors, vancomycin), infections (Epstein-Barr virus), autoimmune diseases (Sjogren's syndrome, lupus nephritis), and other conditions.
  • Clinical Features and Diagnosis: Research articles describe the clinical manifestations of AIN, highlighting the challenges in diagnosis and the importance of renal biopsy. Some studies discuss the association of certain racial backgrounds (Indo-Asians) with an increased risk of AIN.
  • Treatment and Outcomes: Various studies evaluate the effectiveness of steroid therapy and other treatments like mycophenolate mofetil for AIN. Articles also focus on predicting long-term outcomes and the impact of early intervention.
  • Biomarkers and Pathogenesis: Research investigates the role of various biomarkers, including urinary eosinophils and neutrophil gelatinase-associated lipocalin, in reflecting renal damage and guiding diagnosis. Several studies also look into the pathology of IgG4-related AIN.

The collection offers a comprehensive overview of current research on AIN, helping clinicians understand and manage this potentially serious kidney condition.

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